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The August 2006 issue of Circulation magazine— “Anabolic Deficiency in Men with Chronic Heart Failure/Prevalence and Detrimental Impact on Survival.”

The studied looked at four variables in men with CHF (congestive heart failure)  : (1) circulating total testosterone ; (2) free testosterone; (3) DHEA; and (4) insulin-like growth factor-1 (IGF-1).

They concluded men:

  • Men with CHF had hormone deficiencies in all four categories, most averaged out in the lower 10th percentile of their peers.
  • Survival rates of men with CHF and a hormone deficiency in one of these categories showed a 74% three-year survival rate. Those having deficiencies in two had a 55% three-year survival rate; and  those with deficiencies in all three had a 27% three-year survival rate.
  • Men with CHF but no deficiencies in any of the four hormone classes had the best three-year survival rate at 83%.


Men who have a low testosterone level after age 40 may have a higher risk of death over a four-year period than those with normal levels of the hormone, according to a report in the August 14/28 issue of the Archives of Internal Medicine.

  • Low testosterone correlated with higher mortality rates

........Molly M. Shores, M.D., and colleagues at the VA Puget Sound Health Care System and University of Washington, Seattle, studied the relationship between hormone levels and death in a total of 858 male veterans older than age 40 years. All participants received care in the VA Puget Sound Health Care System and had their testosterone levels checked at least twice between 1994 and 1999, with at least one week and no more than two years elapsing between tests. The men were followed for an average of 4.3 years and a maximum of eight years, through 2002

...................... Men with low testosterone levels were still 68 percent more likely to have died. "The persistence of elevated mortality risk after excluding early deaths suggests that the association between low testosterone and mortality is not simply due to acute illness," they write. "Large prospective studies are needed to clarify the association between low testosterone levels and mortality."
(Arch Intern Med. 2006;166:1660-1665

Study Finds No Direct Links Between Testosterone Therapy, Diseases
A retrospective analysis by researchers at Beth Israel Deaconess Medical Center published in The New England Journal of Medicine found no causal relationship between testosterone replacement and prostate cancer or heart disease risk


Low testosterone level is an independent determinant of endothelial dysfunction in men.
Hypertens Res. 2007 Nov;30(11):1029-34
PMID: 18250551



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