The August 2006 issue of Circulation
magazine— “Anabolic Deficiency in Men with Chronic Heart
Failure/Prevalence and Detrimental Impact on Survival.”
The studied looked at four variables in men with
CHF (congestive heart failure) : (1) circulating total
testosterone ; (2) free testosterone; (3) DHEA; and (4) insulin-like
growth factor-1 (IGF-1).
They concluded men:
- Men with CHF had
hormone deficiencies in all four categories, most averaged out
in the lower 10th percentile of their peers.
- Survival rates of men with CHF and
a hormone deficiency in one of these categories showed a 74%
three-year survival rate. Those having deficiencies in two had a
55% three-year survival rate; and those with
deficiencies in all three had a 27% three-year survival rate.
- Men with CHF but no
deficiencies in any of the four hormone classes had the best
three-year survival rate at 83%.
TESTOSTERONE LEVELS ASSOCIATED WITH INCREASED RISK OF DEATH IN MEN
Men who have a low testosterone level after age 40
may have a higher risk of death over a four-year period than those
with normal levels of the hormone, according to a report in the
August 14/28 issue of the Archives of Internal Medicine.
- Low testosterone correlated with higher
........Molly M. Shores, M.D., and colleagues at
the VA Puget Sound Health Care System and University of Washington,
Seattle, studied the relationship between hormone levels and death
in a total of 858 male veterans older than age 40 years. All
participants received care in the VA Puget Sound Health Care System
and had their testosterone levels checked at least twice between
1994 and 1999, with at least one week and no more than two years
elapsing between tests. The men were followed for an average of 4.3
years and a maximum of eight years, through 2002
...................... Men with low testosterone
levels were still 68 percent more likely to have died. "The
persistence of elevated mortality risk after excluding early deaths
suggests that the association between low testosterone and mortality
is not simply due to acute illness," they write. "Large
prospective studies are needed to clarify the association between
low testosterone levels and mortality."
Intern Med. 2006;166:1660-1665
Study Finds No Direct Links Between
Testosterone Therapy, Diseases
A retrospective analysis by researchers at
Beth Israel Deaconess Medical Center published in The New England
Journal of Medicine found no causal relationship between
testosterone replacement and prostate cancer or heart disease risk
Low testosterone level is an independent
determinant of endothelial dysfunction in men.
Res. 2007 Nov;30(11):1029-34
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